Formulation and evaluation of an anti-inflammatory gel containing 2.5% Capparis Brevispina Extract

BARAM, ASHA NAND and SUDHAKAR, MUVVALA and NANGUNOORI, RACHANA and NADIMINTI, DEEPIKA and NALUVALA, NAMITHA and NANDED, MANOGNA and PANJALA, SAIKIRAN (2025) Formulation and evaluation of an anti-inflammatory gel containing 2.5% Capparis Brevispina Extract. World Journal of Advanced Research and Reviews, 25 (3). pp. 2141-2151. ISSN 2581-9615

This study successfully formulated and evaluated an anti-inflammatory gel containing 2.5% Capparis Brevispina extract, traditionally known for its analgesic and anti-inflammatory properties. The goal was to develop a stable, effective, and user-friendly topical gel as a natural alternative for inflammation management. The formulation incorporated appropriate gelling agents, penetration enhancers, and stabilizers to ensure the desired consistency, spreadability, and ease of application. Several formulations were prepared and optimized based on their rheological and physical characteristics. The gel underwent evaluations for pH, viscosity, spreadability, homogeneity, and stability under various storage conditions. The skin-friendly pH minimized irritation, while optimized viscosity ensured easy application and adhesion. Homogeneity tests confirmed uniform distribution of the extract, and spreadability studies indicated smooth application. Stability tests were conducted to assess changes in appearance, texture, or phase separation over time, confirming the gel’s integrity under varying humidity and temperature conditions, making it suitable for long-term storage. The findings demonstrated that the gel met pharmaceutical quality standards, validating its potential as a viable herbal formulation for inflammation management. Overall, this study highlights the successful development of a Capparis Brevispina-based anti-inflammatory gel with promising therapeutic benefits. Further research and clinical evaluations are necessary to establish its efficacy and safety, contributing to the advancement of herbal-based pharmaceutical formulations.