Coinfection of Nontuberculous mycobacteria with Aspergillus fumigatus and Nocardia nova in immunocompromised patient: A case report and literature review

Zabadanova, Sofia Vasileva and Hinkov, Georgi Stoykov and Boyadzhieva, Asena Sava (2025) Coinfection of Nontuberculous mycobacteria with Aspergillus fumigatus and Nocardia nova in immunocompromised patient: A case report and literature review. World Journal of Advanced Research and Reviews, 25 (3). pp. 1307-1314. ISSN 2581-9615

Nontuberculous mycobacteria primarily affect individuals with chronic lung diseases and compromised immune status. Coinfections with other pathogens such as Mycobacterium tuberculosis, Aspergillus spp. and Histoplasma capsulatum are possible. These coinfections worsen prognosis and are associated with increased morbidity and mortality. Diagnosis and effective treatment are often challenging, raising many questions for clinicians regarding polypharmacy, drug interactions, and the management of the underlying disease. We present a clinical case of a patient with ANCA-negative vasculitis and coinfection with Mycobacterium avium, Aspergillus fumigatus and Nocardia nova.