Non-steroidal anti-inflammatory drugs induced oligohydramnios in second trimester pregnancy: A case report

Acharya, Sholen and Rath, Deepak (2025) Non-steroidal anti-inflammatory drugs induced oligohydramnios in second trimester pregnancy: A case report. World Journal of Advanced Research and Reviews, 25 (2). pp. 2693-2696. ISSN 2581-9615

We present a case of oligohydramnios induced by NSAID use (Etoricoxib and Diclofenac) in the second trimester. A 20-year-old primigravidae with an uncomplicated early trimester, was advised at 21 weeks to take Etoricoxib for five days due to knee bursitis after which she self-medicated with Diclofenac for a week. Due to complaints of reduced fetal movement, a scan was done at 23 weeks which revealed reduced liquor status. She was advised against NSAID use and followed up with a scan three weeks later which showed a reversal of oligohydramnios. While NSAIDs are discouraged in the third trimester, limited awareness exists regarding second-trimester risks, especially with self-medication. But our case emphasizes the need for strict monitoring while using NSAIDs even during the second trimester of pregnancy. This case is one of the earliest documented cases involving the adverse effect of Etoricoxib, a selective COX-2 inhibitor, on pregnancy and further study is required to look for long-term effects.